Micky van de Ven Double Ends Everton's Run at New Home Ground
Micky van de Ven emerged as the initial backline player to net twice in a English top-flight game for Spurs since the Belgian defender in spring 2013.
At a glance
The Spurs defender nods home twice in first half
The home side's defender has goal ruled after video check
Pape Matar Sarr nets third in dying moments
The defeat is the Merseyside club's initial at their new ground
The Tottenham defender scored on two occasions as Tottenham extended their unbeaten run in away games in the top division and handed the Toffees their first defeat at their new home.
The Toffees were undefeated in their last five matches at their recently opened stadium at Bramley-Moore Dock, having departed Goodison Park behind after 133 years at the conclusion of last season.
But Tottenham's leader Van de Ven struck on two occasions from corners in the opening 45 minutes to place their strong form at risk, and they were failed to mount a comeback before Pape Matar Sarr - set up by ex-Everton forward the Brazilian - nodded in a third to put the game to bed.
Jake O'Brien thought he had levelled the tally a short while after the defender's first goal, directing a powerful header past Guglielmo Vicario from an set-piece.
The Portuguese striker, meanwhile, missed a handful of chances, while Vicario made a succession of excellent stops to guarantee the London club went five matches on the road unbeaten in the Premier League.
But the video assistant referee intervened, advising Craig Pawson to check the score on the screen and the official ruled that the winger and Iliman Ndiaye were in offside positions and had impeded with the Spurs keeper.
This victory elevates Thomas Frank's team up to third in the Premier League, five points off north London rivals and table-toppers Arsenal.
The Merseyside club stay in 14th position and sit half a dozen points clear of the drop zone.
Spurs breakdown: Van de Ven fulfils role at each end of the field
Following a uninspiring weekday performance in the Champions League against the French side, where they managed a only two shots on goal, Frank chose Randal Kolo Muani up front instead of former Toffees player Richarlison.
The new arrival was unable to make much of an impact before being substituted for Richarlison after 60 minutes on the field, but it turns out he wasn't needed in the end.
Defender Van de Ven converted into an attacking force to be feared.
Spurs' opening strike came from a cleverly executed corner routine, with Rodrigo Bentancur directing the ball back across the face of goal for an free Van de Ven to head home.
And Ven de Ven - filling in as captain in Cristian Romero's unavailability - added his second in first-half stoppage time as he rose above the England keeper to nod in.
Van de Ven was equally outstanding in defence, combining effectively with his defensive colleague as the duo dealt superbly with the numerous deliveries sent their way by the opposition.
Everton analysis: Toffees lacking finishing touch
Everton's recent stadium had been a happy hunting ground, but it seems the novelty may have faded somewhat and fans flocked to the exits after Sarr's final goal for Spurs.
The break in the team's winning streak at home will not be a major worry for the manager, but their striker situation are.
The forward and the other striker - the Everton's two established strikers - had netted just one league goal between them before Sunday's outing.
And they were failed to add to that poor tally on a damp and dreary night on Merseyside.
The striker's performance was epitomized when he chose to bicycle-kick a clear chance from near the goal, despite having space and opportunity to reposition for a more conventional shot that would have tested Vicario.
The substitute, too, was unable to make an impact after coming on for the starter in the second half.
It was not for a shortage of chance. The majority of the home side's offensive moves came through Grealish and Ndiaye, who tirelessly whipped dangerous balls into the Tottenham penalty area.
Upcoming fixtures for both teams?
Everton: The team head to the Stadium of Light in the Premier League on Monday, 3 November at 8 PM.
Spurs: Spurs travel to Newcastle's ground on late October for their next round Carabao Cup tie against Newcastle.